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Abstract
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In this paper, the results of our studies on the catalyst-free synthesis of some new 6-aminouracils bearing naphthoquinone,
benzo[a]phenazine, benzo[f]pyrido[2,3-b]quinoxaline, and benzo[f]quinoxaline substituents are reported. At first, 6-amino-
5-(3,4-dioxo-1-naphthalenyl)uracil derivatives were synthesized from the reaction of various 6-aminouracils with 1,2-
naphthoquinone in DMSO at 70 C in good to excellent yields. Subsequently, the prepared 6-amino-5-(3,4-dioxo-1-
naphthalenyl)uracils were subjected to the condensation reaction with various vicinal diamines, in chloroform under reflux
conditions to synthesize 6-aminouracils bearing benzo[a]phenazine, benzo[f]pyrido[2,3-b]quinoxaline, and
benzo[f]quinoxaline derivatives.
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