16 آذر 1400

اسماعیل تماری

مرتبه علمی:
نشانی: دانشکده علوم و فناوری نانو و زیستی - گروه شیمی
تحصیلات: شیمی تجزیه
تلفن:
دانشکده: دانشکده علوم و فناوری نانو و زیستی

مشخصات پژوهش

عنوان Electrochemical Oxidation of Acetaminophen in the Presence of Barbituric Acid Derivatives
نوع پژوهش مقالات در نشریات
کلیدواژه‌ها
ثبت نشده‌است!
مجله JOURNAL OF THE ELECTROCHEMICAL SOCIETY
شناسه DOI
پژوهشگران اسماعیل تماری (نفر اول) ، مریم کاظمی (نفر دوم) ، آمنه امانی (نفر سوم)

چکیده

Electrochemical oxidation of acetaminophen (1) in the presence of barbituric acid (2a), 1,3-dimethyl barbituric acid (2b), 2- thiobarbituric acid (2c) and 1,3-diethyl-2-thiobarbituric acid (2d) as nucleophiles in aqueous solution has been studied using cyclic voltammetry and controlled-potential coulometry. The results indicate that the p-quinone imine derived from electrooxidation of acetaminophen (1) participates in a Michael addition reaction with 2a-d to form the corresponding barbituric acid derivatives (7a-d). In addition, the homogeneous rate constants were estimated by comparing the experimental cyclic voltammetric responses with the digital simulated results. The electrochemical synthesis of 7a-d has been successfully performed in an undivided cell in good yields and purity at biological pH.