06 آبان 1400

محمد عباسی

مرتبه علمی:
نشانی: دانشکده علوم و فناوری نانو و زیستی - گروه شیمی
تحصیلات: شیمی آلی
تلفن:
دانشکده: دانشکده علوم و فناوری نانو و زیستی

مشخصات پژوهش

عنوان One-pot synthesis of thia-Michael products from thio acids, epoxides, and electron-deficient alkenes promoted by a silica gel/Et3N combined catalyst
نوع پژوهش مقالات در نشریات
کلیدواژه‌ها
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مجله TETRAHEDRON LETTERS
شناسه DOI
پژوهشگران محمد عباسی (نفر اول)

چکیده

An efficient method for the one-pot production of thia-Michael adducts using thio acids, epoxides, and electron-deficient alkenes is described. Epoxides quickly underwent nucleophilic ring-opening with thio acids on the silica gel surface at room temperature under solvent-free conditions to yield b-hydroxy thioester intermediates. After addition of an electron-deficient alkene and a catalytic amount of Et3N to the reaction mixture, the b-acyloxy mercaptans were generated in situ and subsequently underwent thia-Michael addition reactions to produce the corresponding adducts in good to excellent yields.