محمد عباسی

A CuI-catalyzed condensation reaction between alcohols, alkyl halides, and Na2S2O3 leading to structurally diverse thioethers is reported. A variety of alkyl halides and electron-rich benzyl alcohols were employed successfully in the presence of 5 mol% CuI in PEG-200 at 110 C. The method does not require any ligands or additives. The unsymmetrical thioethers were achieved in good to excellent yields within appropriate reaction times.