محمد رضا محمدی زاده

Nitrogen-containing heterocyclic compounds, especially with the core-acridine skeleton, are very promising and noteworthy targets because of their remarkable array of bioactivity profiles such as anti-helmintic and antitumor activities.1 Pyrroloacridone derivatives are of interest owing to their various pharmacological and biological activities.2 Derivatives of pyrroloacridine exhibit promising biological activities such as anthelmintic and anticancer activity.3 Some of these compounds inhibit the growth of cancerous cells via binding to DNA, whereupon they offer potential lead frameworks for developing novel anticancer drugs.4 In continuation of our previous works on the synthesis of N-containing heterocycles5, herein, we try to report a new one-pot three-component procedure for the synthesis of pyrroloacridine derivatives. The reactions were carried out based on the reaction of aromatic amines, isatins, and dimedone in ethanol, under reflux conditions, and in the presence of copper (II) acetate as catalyst. The reactions were completed in 1h and the products were easily obtained by simple filtration of reaction mixture and recrystallization of crude products from ethanol.