09 فروردین 1403
رضا آذين

رضا آذین

مرتبه علمی: استاد
نشانی: دانشکده مهندسی نفت، گاز و پتروشیمی - گروه مهندسی نفت
تحصیلات: دکترای تخصصی / مهندسی نفت
تلفن: -
دانشکده: دانشکده مهندسی نفت، گاز و پتروشیمی

مشخصات پژوهش

عنوان Fabrication, characterization and in vivo evaluation of dexpanthenol sustained-release nanofibers for wound healing
نوع پژوهش مقالات در نشریات
کلیدواژه‌ها
Electrospinning; Drug delivery; Alginate; Chitosan; Isotherm models
مجله POLYMER TESTING
شناسه DOI 10.1016/j.polymertesting.2020.106827
پژوهشگران مریم نجفی اصل (نفر اول) ، شهریار عصفوری (نفر دوم) ، رضا آذین (نفر سوم) ، ساسان زائری (نفر چهارم)

چکیده

In this study, wound dressings consisting of dexpanthenol (Dex)-loaded electrospun nanofibers were fabricated using polyvinyl alcohol (PVA)/ sodium alginate (SA), and chitosan as the core and the shell, respectively. Considering the remarkable properties of chitosan, it was used as a shell against drug release and to improve the thermal stability, and tensile strength of the scaffold. By comparing the thermogravimetric, and tensile strength results of nanofibers with and without shell, it was revealed that the presence of chitosan in the shell side could improve the thermal stability and increased the tensile strength by about three times. The isotherm models of dexpanthenol release from the PVA/SA/Dex-CS scaffold was best described by the Langmuir model. Besides, Fourier transform infrared, scanning electron microscopy, and X-ray diffraction techniques were performed to characterize nanofibers. Furthermore, an in vivo investigation of a wound dressing with dexpanthenol showed better healing compared to the wound dressings without dexpanthenol.