In this research, a novel delay-dependent composite nonlinear feedback (CNF) control would be pointed for nonlinear time-delay systems under actuator saturation. For this aim, firstly, the CNF controller would be formulated in the constrained time-delay systems. Then, a linear matrix inequality (LMI) approach is presented to obtain the controller parameters. Hence, the control synthesis of the constrained nonlinear time-delay systems is transformed into an optimization problem subjected to some LMIs. The suggested controller is simulated in some numerical examples like a chemical reactor with separator and recycle. The computed quantitative results will demonstrate the capability of the proposed CNF control approach compared to other best methods.