Amirhossein Ahmadi

Background: The SARS virus, which belongs to the Coronaviridae family, first emerged in Wuhan, China, in 2019. This virus is recognized by the ACE 2receptor and enters the host's body, causing disease. Objective: To study and examine the single nucleotide polymorphism of the ACE 2gene at the position (rs1463669655) and its association with the severity of COVID- 19patients. Methodology: In this study, 150peripheral blood samples were collected from COVID- 19patients, including 90patients with mild symptoms and 60 patients with severe symptoms, from the Persian Gulf and Social Security hospitals in Bushehr Province, Iran. DNA was extracted from white blood cells and saliva using the phenol-chloroform method. The A and G alleles were determined in both mild and severe groups using PCR and sequencing methods. Data analysis and the association of A and G alleles with the severity of COVID- 19were performed using SPSS software. Findings: Our findings indicate that, similar to other infectious diseases caused by RNA viruses, genetic variations in the 4IFNL gene may increase the likelihood of contracting COVID-19. In both the mild and severe groups, the frequency of the G genotype was lower than that of the A genotypes. Overall, COVID- 19patients in Bushehr Province, Iran, had the A allele, and the frequency of allele G did not show a direct correlation with disease severity. Conclusion: Analysis of the data revealed that the study and examination of the single nucleotide polymorphism of the ACE 2gene at the position (rs1463669655) showed no significant association with the severity of COVID- 19patients in Bushehr Province.