بررسي نقش دوگانه مخلوط فرازودگداز اوره:مس (II) كلريد دوآبه (حلال و كاتاليزور) در سنتز پيوند آميدي از مسير جفتشدن اكسايشي آلدهيدها و آمينها, By Dariush Saberi

Research

Title	Investigating the Dual Role of the Deep Eutectic Mixture Urea:CuCl2.2H2O (solvent and catalyst) in the synthesis of amide bonds through the oxidative coupling of aldehydes and amines.
Type	Thesis
Keywords	حلال فرازودگداز، پيوند آميدي، شيمي سبز، جفت شدن اكسايشي، كاتاليزور مس
Researchers	vida ravanbakhsh (Student) , Dariush Saberi (First primary advisor) , Mohammad Reza Mohammadizadeh (Advisor)

Abstract

In this thesis, a simple, cost-effective, efficient, and one-pot method for the synthesis of benzamides has been developed. In this method, aldehyde derivatives and amine hydrochloride salts react in the presence of a deep eutectic solvent (DES) composed of urea and copper(II) chloride dihydrate, which acts as both catalyst and green solvent. The products were synthesized with moderate to good yields within 6 to 8 hours at 80 °C. The structures of various benzamide derivatives were identified and confirmed after isolation from the reaction medium using chromatographic techniques and spectroscopic analysis.