Sonochemistry has emerged as a transformative methodology in modern chemical synthesis, capitalizing on the unique physicochemical effects of ultrasonic irradiation to drive and enhance chemical reactions. Unlike conventional thermal approaches, which often necessitate harsh conditions, sonochemical techniques facilitate rapid reaction kinetics at ambient temperatures, enabling the formation of nanostructured materials with controlled size, morphology, and enhanced reactivity. The underlying mechanism involves acoustic cavitation, the formation, growth, and implosive collapse of microbubbles in a liquid medium, generating localized extreme temperatures (>5000 K) and pressures (>1000 atm), alongside intense shear forces. These transient yet highly energetic conditions promote unusual reaction pathways, improve mass transfer, and reduce diffusion limitations, thereby optimizing synthetic efficiency. Recent advancements have demonstrated the efficacy of sonochemistry in the synthesis of copper-based supramolecular compounds, which exhibit remarkable structural diversity and functional versatility. These compounds were meticulously characterized using a comprehensive suite of analytical techniques, including Fourier-transform infrared spectroscopy (FTIR) for functional group identification, Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) for morphological evaluation, Thermogravimetric analysis (TGA) for thermal stability assessment, X-ray powder diffraction (XRPD) and single-crystal X-ray diffraction (SCXRD) for crystallographic elucidation. Biological evaluations revealed that these supramolecular architectures exhibit potent antioxidant activity, alongside selective cytotoxicity against fibroblast and MCF-7 breast cancer cell lines, suggesting potential therapeutic applications. Hemocompatibility studies indicated minimal hemolytic activity, reinforcing their suitability for biomedical use. Furthermore, antibacterial assays demonstrated e