Khosro Mohammadi

Anovelone-dimensional mercurycoordination polymer (CP), identifed as [(μ2-Cl)(Ina)Hg(μ3-Cl)Hg(μ2-Cl)2(Ina)]n (1) (where Ina represents isonicotinic acid or 4-pyridinecarboxylic acid), was synthesized via the interaction of isonicotinic acid with mercury(II) salt. This synthesis was achieved through two distinct experimental approaches: layering methods for the formation of single crystals (1) and sonochemical irradiation for the production of nanostructures (1′). The structural characterization of (1) was performedusingX-raydifractionandcrystallographytechniques. Furthercharacterizationinvolved a rangeof methods, including X-ray powder difraction (XRD), infrared (IR) spectroscopy, scanning electron microscopy (SEM), thermogravimetric analysis (TGA),andHirshfeld surface analysis (HSA). The CPof (1)features twotypes of metalcenters, exhibiting coordination numbers of 5 and 6. In this structure, each mercury atom is coordinated to chlorine, nitrogen, and oxygen atoms derived from the ligands. Additionally, antibacterial properties were tested on seven Gram-positive bacteria and nine Gram-negative bacteria. Anticancer properties were tested on both OCAR3 (cancer) and VERO (normal) cells; as a result, the antibacterial and anticancer activities of nanoparticle [(μ2-Cl)(Ina)Hg(μ3-Cl)Hg(μ2-Cl)2(Ina)]n (1′) were evaluated, revealing that the antibacterial efcacy of the nano particles was comparable to that of standard antibiotics. The anticancer properties were efective in destroying cancer cells while preserving the integrity of normal cells. Consequently, both antibacterial and anticancer properties demonstrated promising results.