Sedigheh Hashemnia

Olanzapine belongs to the class of atypical antipsychotic drugs for the schizophrenia and bipolar disorder. Olanzapine is structurally similar to clozapine, but is classified as a thieno-benzodiazepine. In this work the electrochemical oxidation of olanzapine has been studied in the absence and presence of sodium thiopental in acetonitrile solution, using cyclic voltammetry and controlled potential coulometry. A cyclic voltammetric was performed by carbon electrodes. The potential values range has been considered from -0.3v to 0.8v. To determine the mechanism, the effect of scan rate was first examined. After recording the voltammograms from olanzapine, sodium thiopental and olanzapine with nucleophile, a coulometry was performed to discover the mechanism. Coulometry was performed in a double-walled cell containing three graphite electrodes, a reference electrode Ag/AgCl, and a platinum electrode at constant potential. The electrochemical synthesis of thiese compounds has been successfully performed. After completing the electrolysis process and performing calculations, the amount of 2e for each molecule of olanzapine was obtained. Spectroscopic studies were also carried out to ensure the results of electrochemical evidence. After examining the infared and MS spectra, the mechanism of EC was achieved for the electrochemical oxidative of olanzapine and sodium thiopental.