Sara Zare karizak

Background & Aim: High-Intensity exercise is accompanied by inflammation and oxidative stress. This study aimed to investigate the effect of the FIFA test with curcumin supplementation on serum MDA, TAC, and CRP in male football assistant referees. Methods In this semi-experimental study, 20 football assistant referees (mean age 28.56±3.75 years, height 179±4.21 cm, weight 72.78±7.08 kg) were selected voluntarily and then were randomly assigned to the curcumin + FIFA test and the FIFA test groups. The test + supplement group, in addition to FIFA tests, received 5 grams of curcumin daily for five days. Blood samples were collected in three stages, and serum levels of variables were measured using the spectrophotometric method. Repeated-measures ANOVA and Bonferroni post hoc tests were performed in SPSS26. Results There was a significant increase in serum CRP, MDA, and TCA in both groups in the first post-test (P<001, P=0.041, P=0.008, P=0.009, P= 0.048, P=0.014). Also, in the second post-test of the test group, the increase in CRP and MDA levels remained significant (P < 0.001, P = 0.022). However, TAC became a non-significant increase (P=0.160), while its increase in the test + supplement group was still significant (P=0.013), and in the test + supplement group, MDA became a non-significant increase compared to the pre-test (P=0.186), while in the test group it still had a significant increase (P=0.022).In addition, there was a significant difference between the groups in CRP and TAC values (P=0.024, P=0.05) and a non-significant difference in MDA levels (P=0.129). Conclusion Curcumin modulates some of the inflammatory and oxidative stress indices due to the FIFA test