Upregulatory action of antioxidative genes potentiates Capsicum chinense Jacq as an antidiabetic functional food evident in biochemical, histopathological, and network pharmacological impacts, By gholamreza Abdi

Research

Title	Upregulatory action of antioxidative genes potentiates Capsicum chinense Jacq as an antidiabetic functional food evident in biochemical, histopathological, and network pharmacological impacts
Type	Article
Keywords	Capsicum chinense Diabetes mellitus Superoxide dismutase 1 Glutathione peroxidase Network pharmacology
Journal	Journal of Functional Foods
DOI	https://doi.org/10.1016/j.jff.2024.106103
Researchers	Srabonti Saha (First researcher) , Fatema Yasmin Nisa (Second researcher) , Mumtahina Majid (Third researcher) , Md. Khalid Juhani Rafi (Fourth researcher) , Tanvir Ahmed Siddique (Fifth researcher) , Farjana Sultana (Not in first six researchers) , Asif Nadim Khan (Not in first six researchers) , A.M. Abu Ahmed (Not in first six researchers) , Md Atiar Rahman (Not in first six researchers) , gholamreza Abdi (Not in first six researchers)

Abstract

This research characterized the organic extracts of Capsicum chinense by GCMS and LCMS analyses and investigated their antidiabetic potentials in a fructose-fed streptozotocin (STZ)-induced model. The organic extracts were found to display a promising in vitro inhibition of α-amylase and α-glucosidase and in vivo decrease of serum glucose levels, ALP, ALT, AST, creatinine, uric acid, and lipid levels. They upregulated the antioxidative CAT, SOD1, GPx, and PFK1 gene expressions and restored the pancreas, liver, and kidney architectures. Multitarget interactions of C. chinense metabolites forcibly modulated the AKT1 and PIK3R1 proteins demonstrating the prospective functional food potential of C. chinense.