The purpose of this research was to predict moral harm via religious orientation and psychological hardiness students. Research method was correlation and its statistical population was all male and female students of high school in Boushehr city. The samples of this study included 400 students which were selected through classified random sampling. Research tools were including researcher’s made questionnaire of moral vulnerability, religious orientation questionnaire, and psychological hardiness questionnaire. Two factors analysis of variance showed girls’ students have an upper hardiness and students with internal religious orientation in compare students with external religious orientation have an upper psychological hardiness and lower moral vulnerability. Also, Regression analysis showed factors of internal religious orientation, external religious orientation, and psychological hardiness have a significant ratio in prediction of moral vulnerability.