Background: Despite advances in the treatment and overall reduction of coronary artery disease (CAD) mortality, the disease remains the number one cause of death in both men and women. A group of people with CAD get the disease at a younger age than others, in which case it is called early CAD. Early CAD increases the risk of major advance cardiac events (MACE). MACE is a clinical endpoint often used in cardiovascular research, including hospitalization for heart failure (HF), myocardial infarction (MI), stroke, and reperfusion involving percutaneous coronary intervention (PCI). And coronary artery bypass graft (CABG) surgery. Although studies on the mechanism of occurrence of MACE in patients with CAD have been performed so far, the molecular events of MACE in patients with early CAD are not fully understood, which makes this study important. Previously, a significant association between the type 2 allele of the haptoglobin (Hp) gene with the occurrence of MACE has been reported in diabetic patients with CAD. Aim:The aim of this study was to investigate the association of alleles of this gene with the occurrence of MACE in patients with premature coronary artery disease.
Methodology: In this nested case-control study, peripheral blood samples from 138 young patients with premature CAD (men less than 45 years and women less than 55 years) were among a group of patients with coronary artery disease in the atherosclerotic cohort. Coronary arteries (THC-PAC) of the Tehran Heart Center participated and were monitored for MACE for 64 months. DNA extraction from white blood cells was performed using phenol-chloroform method. The type of haptoglobin allele in patients was determined by PCR. Data analysis and the relationship between haptoglobin alleles and MACE were performed using SPSS software and p-value less than 0.05 was considered as a significant level.
Conclusion: Although there was no significant relationship between type 2 allele of haptoglobin and MACE (p-value