Crosstalk between lncRNAs in the apoptotic pathway and therapeutic targets in cancer, By Amirhossein Ahmadi

Research

Title	Crosstalk between lncRNAs in the apoptotic pathway and therapeutic targets in cancer
Type	Article
Keywords	LncRNAs, Apoptosis, Cancer therapy, Biomarkers, Therapeutic target
Journal	CYTOKINE & GROWTH FACTOR REVIEWS
DOI	https://doi.org/10.1016/j.cytogfr.2022.04.003
Researchers	Nasim Ebrahimi (First researcher) , Sahar Parkhideh (Second researcher) , Setare Samizade (Third researcher) , Alireza Nasr Esfahani (Fourth researcher) , Sahar Samsami (Fifth researcher) , Elnaz Yazdani (Not in first six researchers) , Samaneh Adelian (Not in first six researchers) , Siavash Rahimian Chaleshtori (Not in first six researchers) , Kamal Shah Amiri (Not in first six researchers) , Amirhossein Ahmadi (Not in first six researchers) , Amir Reza Aref (Not in first six researchers)

Abstract

The assertion that a significant portion of the mammalian genome has not been translated and that non-coding RNA accounts for over half of polyadenylate RNA have received much attention. In recent years, increasing evidence proposes non-coding RNAs (ncRNAs) as new regulators of various cellular processes, including cancer progression and nerve damage. Apoptosis is a type of programmed cell death critical for homeostasis and tissue development. Cancer cells often have inhibited apoptotic pathways. It has recently been demonstrated that up/down-regulation of various lncRNAs in certain types of tumors shapes cancer cells' response to apoptotic stimuli. This review discusses the most recent studies on lncRNAs and apoptosis in healthy and cancer cells. In addition, the role of lncRNAs as novel targets for cancer therapy is reviewed here. Finally, since it has been shown that lncRNA expression is associated with specific types of cancer, the potential for using lncRNAs as biomarkers is also discussed.