A green practical method for the ef?cient synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)triones
using sulfuric acid-modi?ed polyethylene glycol-6000 (PEG-OSO
3
H) as an eco-friendly polymeric
catalyst from the four-component condensation reaction of phthalic anhydride, hydrazinium hydroxide,
1,3-cyclohexanedione or 5,5-dimethyl 1,3-cyclohexanedione (dimedone) and aromatic aldehydes under
solvent-free conditions at 80
C is described. This approach allowed the environmental impact factor
(E-factor) to be minimized.
?