Abstract: In this work, a green, simple and highly efficient procedure for the preparation of 1,8-
dioxo-octahydroxanthene and 1,8-dioxo-decahydroacridine derivatives [as biologically active heterocycles, fluorescence materials and Pharmaceutical compounds] is described. Sulfonated Polyethylene glycol (PEG-SO
3
H) has been used as an efficient and reusable catalyst for the one-
pot multi component domino condensation reaction of dimedone and an aromatic aldehyde without/and a primary amine. The reactions were completed at 80 o
C in water as green solvent. Using this procedure, all the products were obtained in good to excellent yields. The catalyst has been recovered and reused several times without any lose of reactivity.