Zinc oxide-tetrabutylammonium bromide tandem as a highly efficient, green, and reusable catalyst for the Michael addition of pyrimidine and purine nucleobases to α,β-unsaturated esters under solvent-free conditions، انجام شده توسط علیرضا حسنی نژاد

مشخصات پژوهش

عنوان	Zinc oxide-tetrabutylammonium bromide tandem as a highly efficient, green, and reusable catalyst for the Michael addition of pyrimidine and purine nucleobases to α,β-unsaturated esters under solvent-free conditions
نوع پژوهش	مقالات در نشریات
کلیدواژه‌ها	Zinc oxide; tetrabutylammonium bromide; Michael addition; pyrimidine; purine; nucleobases
مجله	Canadian Journal of Chemistry
شناسه DOI	10.1139/v08-022
پژوهشگران	عبدالکریم زارع (نفر اول) ، علیرضا حسنی نژاد (نفر دوم) ، محمد حسن بیضاوی (نفر سوم) ، ابوالفتح پرهامی (نفر چهارم) ، احمد رضا موسوی زارع (نفر پنجم) ، علی خلفی نژاد (نفر ششم به بعد) ، هاشم شرقی (نفر ششم به بعد)

چکیده

An efficient procedure for the synthesis of carboacyclic nucleosides via microwave-assisted Michael addition of pyrimidine and purine nucleobases to α,β-unsaturated esters in the presence of catalytic amounts of zinc oxide (ZnO) and tetrabutylammonium bromide (TBAB) is described. The reactions proceed rapidly in good to excellent yields.Key words: ZnO–TBAB, green chemistry, Michael addition, nucleobase, solvent-free, microwave.