Background: In recent years, heterocyclic compounds have attracted much attention due to their wide applications in various fields, especially in medical science and industry. This class of organic compounds is known as important tools in scientific research and development of new technologies due to their special properties and ability to produce beneficial effects. In this regard, the present project focuses on the efficient and monovalent synthesis of different heterocycles using 1,1-bis (methyl thio)-2-nitro ethylene.
Aim: The present study introduces new, facile and partly green chemistry-compliant methods for the one-pot synthesis of spiroindolinone pyrazole, spiroindoline diazepine, highly substituted pyrroles, highly substituted 3,2-dihydropyrroles, chromene and 2-aminopyridine heterocycles based on 1,1-bis (methyl thio)-2-nitro ethylene.
Methodology: In the first part of this research, a green and efficient method with high yield for the synthesis of spiro indolinone pyrazole derivatives has been presented. This synthesis is carried out through the condensation reaction between N-aryl-1-methylthio-2-nitro ethen
amine, isatin derivatives and hydrazine under reflux ethanol conditions. The use of this method not only helps to improve the yield of the final products, but also causes less damage to the environment. Therefore, this research emphasizes the importance and efficiency of green methods in organic chemistry and can be effective in the development of new methods for the synthesis of pharmaceutical and chemical materials.
In the second part of this study, a one-pot, four-component method for the synthesis of spiro indoline diazopine derivatives via the reaction of N-aryl-1-methylthio-2-nitro ethenamine, hydrazine, isatin derivatives, and malononitrile under reflux ethanol conditions is presented. This synthetic method is designed in a way that is consistent with the principles of green chemistry and provides significant advantages. Among these advantages