The lack of water in the world as a fundamental challenge has caused human attention to create new technologies in the field of water desalination. One of the most important technologies in this field is reverse osmosis membrane technology, which provides a significant role in the possibility of water recovery due to their inherent advantage in achieving high permeability and salt rejection; However, according to previous studies, scaling is an inevitable problem in this process, which causedreduced flux, frequent Cleaning, and shorter membrane life. On the other hand, there are different methods to control the formation of fouling, and the use of substances such as antiscalants is the most cost-effective strategy compared to other methods. Therefore, the use of these materials, which prevent the formation of fouling during the purification process and lead to an increase in the flux by destroying the initial nuCleus of the sediment, is very important from an industrial point of view. The present study on a laboratory scale with the aim of investigating the antiscalant performance of APS 3400 and Flucon 260, with concentrations of 2 mg/l and 5 mg/l, on reverse osmosis membrane fouling, according to the water samples of Kalel and Badam-Zar well, water Mond and Baghan rivers, Was performed out in a period of 6 hours and a constant pressure of 11.5 bar, And the necessary analyzes to evaluate the membrane performance such as flux, fouling, as well as FESEM and EDX were analyzed and investigated to check the morphology and salts present on the surface of the membrane. The results of the experiment indicate that by adding antiscalant APS 3400 with a concentration of 2 mg/l to the water of Kalel well and antiscalant Floken 260 with a concentration of 2 mg/l to the water of Badam-Zar and Baghan River and also APS 3400 with a concentration of 5 mg/l to In Mond river water, the increase in flux output from the membrane is observed compared to the state of not using them, whic