This work presents an investigation of CO2 absorption into aqueous blends of AMP DEA. we used the Deshmukh Mather Thermodynamic models to predict the absorption of CO2 into aqueous blended amine. The experimental results show that the solubility of CO2 increase with partial pressure and decreases with temperature. The retrieved data from the literature of CO2 loading in aqueous solutions of AMP DEA at various temperature (303-323K) and CO2 partial pressure (1–100kPa) were fitted simultaneously. We generated the different interaction parameters required to calculate the activity coefficients in the model. By using the generated interaction parameters, the model was applied to correlate the CO2 loading in solutions of this mixture as well as data reported in the literature. Moreover was found that it can be able to give a good estimation of CO2 loading over a wide range of operating conditions.