احمد شادی

Objective: The aim of this study was to review anti-cancer compounds of marine resources and their use in the treatment area. Millions of people suffer from cancer, which is one of the main causes of death in developed countries Efforts on secondary metabolites from marine organisms have been satisfactory and some marine originated drugs approved by the FDA in the field of cancer Understanding how genetic and biochemical level synthesis of these compounds led to the discovery of new drugs with anticancer potential. Methods: Many anti-cancer compounds from marine sources are in clinical stages and some of them are also approved. Bryostatin is a marine macrolide that isolated from bryozoa Bugula neritina and selectively destroys cancer cells, unlike common chemotherapy drugs in the body, stimulates blood. Soblidotin derivatives of Dolastatin 10 and Synthadotin derivatives of Dolastatin 15 which inhibits tubulin polymerization, then prevent cell division and is effective in solid tumors. These compounds have the least side effects and are used for lung as well as prostate cancer .Kahalalide F was isolated from the mollusca Elysia rufescens and disrupt the lysosomal membranes of tumor cells and for tumor cells, such as prostate which have a high lysosomal activities are effective and less sensitive to non-tumor cell lines. Aplidine is a cyclic depsipeptide, isolated from Aplidium albicans and prevents cell division by inhibiting protein synthesis and secretion of VEGF and prevents the angiogenesis process. Jasplakinolide is depsipeptide that isolated from sponge Jaspis sp. and prevents cell division by interfering with the polymerization of actin. Ecteinascidin (ET-743) is an alkaloid isolated from tunicate Ectenaiscidia trubinata which blocks DNA binding of the oncogenic transcription factor FUS-CHOP, therefore promotes differentiation and reverses the oncogenic phenotype in these cells. Results and Discussion: Seas and oceans are a source of bioactive compounds that a