احمد شادی

Today by spreading of existing diseases and emergence of new infections, special attention to the vaccinology is necessary. In the past decade the progress made in the process of gene sequencing, pathogens gene sequencing more rapidly done. That accelerates the process of the new vaccine manufacturing. The protection against invading pathogens and cells infected by viruses aware of the immune system (humoral and cellular immunity) is very important. Aware of this process, it’s necessary in the epitopes prediction process and vaccine design. With respect to the progress made in this field, still tests needed to identify appropriate areas, is costly and requiring inexpensive, practical, fast and with high precision tools is essential. Immunoinformatics was created due to the needs. This science is a branch of bioinformatics, which was formed by bioinformatics fast growing and massive data derived from gene sequencing, immunology and vaccinology. Nowadays many bases as SYFPEITHI, BIMAS, ProPred and NetCTL for T cells and BepiPred, ABCPred, Bcepred for B cells has been created. This article discusses and reviews the available tools to predict the appropriate B and T epitopes for vaccine design.