An Effectual Eco-Friendly Protocol for the Construction of 4,6-Diarylpyrimidin-2(1H)-Ones, By Abdolkarim Zare

Research

Title	An Effectual Eco-Friendly Protocol for the Construction of 4,6-Diarylpyrimidin-2(1H)-Ones
Type	Article
Keywords	Aryl aldehyde; Acetophenones; Urea; 4,6-Diarylpyrimidin-2(1H)-one; Solvent-free; Multi-component reaction
Journal	asian journal of green chemistry
DOI	https://doi.org/10.48309/ajgc.2024.457824.1508
Researchers	Abdolkarim Zare (First researcher) , Roghayyeh Khanivar (Second researcher)

Abstract

An effectual eco-friendly protocol for the construction of 4,6-diarylpyrimidin-2(1H)-ones has been described through a solvent-free one-pot multi-component reaction. The condensation of urea, aryl aldehydes, and acetophenones in the Me3SiCl presence produced 4,6-diarylpyrimidin-2(1H)-ones in high yields and relatively short times. In the reported protocols, a catalyst has been used beside Me3SiCl. However, in our protocol, there was no need to utilize a catalyst.