Efficient method for the direct preparation of amides from carboxylic acids using tosyl chloride under solvent-free conditions, By Abdolkarim Zare

Research

Title	Efficient method for the direct preparation of amides from carboxylic acids using tosyl chloride under solvent-free conditions
Type	Article
Keywords	Amide; Solvent-free; Ammonium salts; Tosyl chloride
Journal	TETRAHEDRON LETTERS
DOI	10.1016/j.tetlet.2005.08.021
Researchers	Ali Khalafi-Nezhad (First researcher) , Abolfath Parhami (Second researcher) , Mohammad Navid Soltani Rad (Third researcher) , Abdolkarim Zare (Fourth researcher)

Abstract

A simple, clean and highly efficient solvent-free procedure for the preparation of primary, secondary, tertiary and aromatic amides is described from the direct reaction of carboxylic acids and silica-supported ammonium salts, triethylamine (TEA) and tosyl chloride (TsCl) as condensing agent.