Trityl Chloride as a Novel and Efficient Organic Catalyst For Room Temperature Preparation of Bis(indolyl)methanes under Solvent-Free Conditions in Neutral Media, By Abdolkarim Zare

Research

Title	Trityl Chloride as a Novel and Efficient Organic Catalyst For Room Temperature Preparation of Bis(indolyl)methanes under Solvent-Free Conditions in Neutral Media
Type	Article
Keywords	Trityl chloride; bis(indolyl)methanes; carbonyl compounds; indole; solvent-free
Journal	SYNTHESIS-STUTTGART
DOI	10.1055/s-2008-1032159
Researchers	A. Khalafi-Nezhad (First researcher) , A. Parhami (Second researcher) , Abdolkarim Zare (Third researcher) , A.R. Moosavi Zare (Fourth researcher) , A. Hasaninejad (Fifth researcher) , F. Panahi (Not in first six researchers)

Abstract

A simple, clean, and highly efficient solvent-free procedure for the preparation of bis(1H-indol-3-yl)methanes is described from the reaction of carbonyl compounds (aldehydes and ketones) with 1H-indole in the presence of trityl chloride as a catalyst. The reaction proceeds rapidly in high yields at room temperature in a neutral medium. A proposed mechanism is suggested based upon former reactions and calculated results.