A Solventless Protocol for Michael Addition of Aromatic Amides to α,β-Unsaturated Esters Promoted by Microwave Irradiation, By Abdolkarim Zare

Research

Title	A Solventless Protocol for Michael Addition of Aromatic Amides to α,β-Unsaturated Esters Promoted by Microwave Irradiation
Type	Article
Keywords	Michael addition, Amide, α,β-Unsaturated ester, Microwave, Protected β-amino acid
Journal	Journal of the Iranian Chemical Society
DOI	10.1007/BF03245822
Researchers	Abdolkarim Zare (First researcher) , A. Hasaninejad (Second researcher) , A. Khalafi-Nezhad (Third researcher) , A. Parhami (Fourth researcher) , A.R. Moosavi Zare (Fifth researcher)

Abstract

A very simple and efficient solvent-free method for the preparation of N-benzoylated β-amino esters (protected β-amino acids) via the microwave-assisted Michael addition of aromatic amides to α,β-unsaturated esters in the presence of Cs2CO3 and tetrabutylammonium bromide (TBAB) is described. The advantages of this method are efficiency, high yields and short reaction times.