Highly efficient synthesis of triazolo[1,2-a]indazole-triones and novel spiro triazolo[1,2-a]indazole-tetraones under solvent-free conditions, By Abdolkarim Zare

Research

Title	Highly efficient synthesis of triazolo[1,2-a]indazole-triones and novel spiro triazolo[1,2-a]indazole-tetraones under solvent-free conditions
Type	Article
Keywords	Combinatorial chemistry; Multi-component reaction; PEG-SO3H Urazole; Triazolo[1,2-a]indazole-triones; Spiro triazolo[1,2-a]indazole-tetraone
Journal	TETRAHEDRON
DOI	10.1016/j.tet.2010.11.029
Researchers	Alireza Hasaninejad (First researcher) , Abdolkarim Zare (Second researcher) , Mohsen Shekouhy (Third researcher)

Abstract

A new, convenient, and high yielding procedure for the synthesis of triazolo[1,2-a]indazole-triones by the condensation reaction between dimedone, aryl aldehydes, and ueazoles in the presence of a catalytic amount of sulfonated polyethylene glycol (PEG-SO3H) as a highly stable and reusable eco-friendly degradable polymeric catalyst is described under solvent-free conditions. This procedure has also been applied successfully for the synthesis of novel spiro triazolo[1,2-a]indazole-tetraones.