Room-Temperature, Catalyst-Free, One-Pot Pseudo-Five-Component Synthesis of 4,4-(Arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s under Ultrasonic Irradiation, By Abdolkarim Zare

Research

Title	Room-Temperature, Catalyst-Free, One-Pot Pseudo-Five-Component Synthesis of 4,4-(Arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s under Ultrasonic Irradiation
Type	Article
Keywords	Bis-pyrazolylmethane, Multi-component reaction, Catalyst-free, Ultrasound irradiation
Journal	ACS Sustainable Chemistry & Engineering
DOI	10.1021/sc400081c
Researchers	Alireza Hasaninejad (First researcher) , Maryam Rasekhi Kazerooni (Second researcher) , Abdolkarim Zare (Third researcher)

Abstract

A green and convenient approach for the synthesis of 4,4-(arylmethylene)bis (3-methyl-1-phenyl-1Hpyrazol-5-ols) by the reaction of aromatic aldehydes, phenylhydrazine derivatives, and ethyl acetoacetate in water/ethanol (1/1) under ultrasound irradiation is described. This method provides several advantages such as environmental friendliness, shorter reaction time, excellent yields, and simple workup procedure.