One pot synthesis of 1,2,4,5-tetrasubstitutedimidazoles catalyzed by trityl chloride in neutral media, By Abdolkarim Zare

Research

Title	One pot synthesis of 1,2,4,5-tetrasubstitutedimidazoles catalyzed by trityl chloride in neutral media
Type	Article
Keywords	1,2,4,5-Tetrasubstitutedimidazoles; trityl chloride; solvent-free; trityl carbocation
Journal	RSC Advances
DOI	10.1039/C4RA10589C
Researchers	Ahmad Reza Moosavi-Zare (First researcher) , Zhila Asgari (Second researcher) , Abdolkarim Zare (Third researcher) , Mohammad Ali Zolfigol (Fourth researcher) , Mohsen Shekouhy (Fifth researcher)

Abstract

Trityl chloride (TrCl or Ph3CCl) efficiently catalyzes the one-pot multi-component condensation of benzil with aldehydes, primary amines and ammonium acetate under neutral and solvent-free conditions to give 1,2,4,5-tetrasubstituted imidazoles in high to excellent yields and in short reaction times. Mechanistically, it is attractive that trityl chloride promotes the reaction by in situ generation of trityl carbocation (Ph3C+).