A green approach for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones (and -thiones) using N,N-diethyl-N-sulfoethanaminium hydrogen sulfate, By Abdolkarim Zare

Research

Title	A green approach for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones (and -thiones) using N,N-diethyl-N-sulfoethanaminium hydrogen sulfate
Type	Article
Keywords	SO3H-containing ionic liquid; N,N-Diethyl-N-sulfoethanaminium hydrogen sulfate {[Et3N–SO3H]HSO4}; 3,4-Dihydropyrimidin-2-(1H)-one, 3,4-dihydropyrimidin-2-(1H)-thione; Arylaldehyde
Journal	JOURNAL OF MOLECULAR LIQUIDS
DOI	10.1016/j.molliq.2016.01.056
Researchers	Abdolkarim Zare (First researcher) , Zahra Nasouri (Second researcher)

Abstract

In this paper, a novel SO3H-containing ionic liquid namely N,N-diethyl-N-sulfoethanaminium hydrogen sulfate ([Et3N–SO3H]HSO4) has been synthesized, and characterized by studying its FT-IR, 1H NMR, 13C NMR and mass spectra. Afterward, catalytic activity of the Brønsted acidic ionic liquid has been examined for the preparation of 3,4-dihydropyrimidin-2-(1H)-ones and 3,4-dihydropyrimidin-2-(1H)-thiones via the one-pot multicomponent reaction between arylaldehydes, β-ketoesters and urea (or -thiourea) under solvent-free conditions. The results showed that [Et3N–SO3H]HSO4 was highly efficient catalyst for this reaction.