Synthesis of b-phthalimido-alcohols via regioselective ring opening of epoxide by using reusable basic magnetic nano particles and their biological investigation, By Abdolkarim Zare

Research

Title	Synthesis of b-phthalimido-alcohols via regioselective ring opening of epoxide by using reusable basic magnetic nano particles and their biological investigation
Type	Article
Keywords	beta-phthalimido-alcohols; epoxide; basic magnetic nanocatalyst; ring opening
Journal	RSC Advances
DOI	10.1039/C6RA07660B
Researchers	Mohammad Ali Zolfigol (First researcher) , Ahmad Reza Moosavi-Zare (Second researcher) , Mahmoud Zarei (Third researcher) , Abdolkarim Zare (Fourth researcher) , Ehsan Noroozizadeh (Fifth researcher) , Roya Karamian (Not in first six researchers) , Mostafa Asadbegy (Not in first six researchers)

Abstract

In this work, tetra butyl ammonium hydroxide ([Bu4N]OH) and magnetic nano particles (Fe3O4@SiO2@(CH2)3NH2) were introduced as efficient catalysts for the regioselective ring opening of epoxides including aromatic and aliphatic of epoxides to give the corresponding b-phthalimido-alcohols under mild conditions. A various range of beta-phthalimido-alcohols as new compounds were prepared and fully characterized by IR, 1H as well as 13C NMR and mass spectra. Also the synthesized compounds were studied for antioxidant properties by DPPH free radical scavenging assay. The results indicated that studied b-phthalimido-alcohols derivatives have effective antioxidant functions in compare with BHT and ascorbic acid as standards. This may be a new health-care food and drug supplement for special use in the future.