A new more atom-efficient multi-component approach to tetrasubstituted imidazoles: one-pot condensation of nitriles, amines and benzoin, By Abdolkarim Zare

Research

Title	A new more atom-efficient multi-component approach to tetrasubstituted imidazoles: one-pot condensation of nitriles, amines and benzoin
Type	Article
Keywords	Atom-efficient multi-component reaction; tetrasubstituted imidazoles; nitriles; amines; benzoin
Journal	RSC Advances
DOI	10.1039/C6RA11171H
Researchers	Ali Khalafi-Nezhad (First researcher) , Mohsen Shekouhy (Second researcher) , Hashem Sharghi (Third researcher) , Jasem Aboonajmi (Fourth researcher) , Abdolkarim Zare (Fifth researcher)

Abstract

A new more atom-efficient multi-component approach for the synthesis of tetrasubstituted imidazoles via the one-pot condensation of nitriles, primary amines and benzoin has been described. Using this method, a wide range of structurally diverse nitriles and primary amines were successfully condensed with benzoin in glycerol in the presence of TFA under microwave irradiation at 120 °C and all the products were obtained in good to excellent yields with higher atom efficiencies in comparison with the commonly used four-component condensation of aldehydes, ammonium acetate, primary amines and benzil.