A Rapid and Highly Effectual Protocol for the Synthesis of Bis-coumarins using Triethylaminium-N-sulfonic Acid Tetrachloroaluminate under Solvent-Free Conditions, By Abdolkarim Zare

Research

Title	A Rapid and Highly Effectual Protocol for the Synthesis of Bis-coumarins using Triethylaminium-N-sulfonic Acid Tetrachloroaluminate under Solvent-Free Conditions
Type	Article
Keywords	Bis-coumarin; 4-Hydroxycoumarin; Protic acidic ionic liquid; Triethylaminium-N-sulfonic acid; tetrachloroaluminate (TSAT); Solvent-free
Journal	CHEMICAL METHODOLOGIES
DOI	10.33945/SAMI/CHEMM.2019.5.8
Researchers	Asieh Kargar-Dolatabadi (First researcher) , Abdolkarim Zare (Second researcher)

Abstract

In this work, a rapid and highly effectual protocol for the synthesis of bis-coumarins has been developed. The one-pot quasi three-component reaction of aromatic aldehydes (1 eq.) with 4-hydroxycoumarin (2 eq.) in the presence of catalytic amount of protic acidic ionic liquid triethylaminium-N-sulfonic acid tetrachloroaluminate (TSAT) under solvent-free conditions afforded the mentioned compounds in high yields and short reaction times.