A simple, rapid and effective protocol for synthesis of bis(pyrazolyl)methanes using nickel–guanidine complex immobilized on MCM-41, By Abdolkarim Zare

Research

Title	A simple, rapid and effective protocol for synthesis of bis(pyrazolyl)methanes using nickel–guanidine complex immobilized on MCM-41
Type	Article
Keywords	Nanocatalyst; Nickel–guanidine complex immobilized on MCM-41 (MCM-41@Gu@Ni); Bis(pyrazolyl)methanes; Phenylhydrazine; Ethyl acetoacetate; Arylaldehyde
Journal	RESEARCH ON CHEMICAL INTERMEDIATES
DOI	10.1007/s11164-019-04073-y
Researchers	Alireza Kohzadian (First researcher) , Hossein Filian (Second researcher) , Zahra Kordrostami (Third researcher) , Abdolkarim Zare (Fourth researcher) , Arash Ghorbani‑Choghamarani (Fifth researcher)

Abstract

In this paper, a rapid, easy and very efficient method for the synthesis of bis(pyrazolyl)methanes has been reported in the presence of nickel–guanidine complex immobilized on MCM-41 (MCM-41@Gu@Ni) as a recyclable nanocatalyst. This mesoporous silica catalyst was effective for the one-pot multi-component reaction of arylaldehydes, phenylhydrazine and ethyl acetoacetate in ethanol solvent. The current synthesis shows attractive features, for example the use of recoverable and reusable nanocatalyst (5 times), easy workup, suitable one-pot procedure, short reaction times, good to excellent yields and moderate reaction conditions.