A highly efficient and green approach for the synthesis of pyrimido[4,5-b]quinolines using N,N-diethyl-N-sulfoethanaminium chloride, By Abdolkarim Zare

Research

Title	A highly efficient and green approach for the synthesis of pyrimido[4,5-b]quinolines using N,N-diethyl-N-sulfoethanaminium chloride
Type	Article
Keywords	6-Amino-1,3-dimethyluracil; acidic ionic liquid; multi-component reaction; N,N-diethyl-N-sulfoethanaminium chloride ([Et3N–SO3H][Cl]); pyrimido[4,5-b]quinoline; solvent-free
Journal	ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
DOI	10.1515/znb-2020-0098
Researchers	Abdolkarim Zare (First researcher) , Manije Dianat (Second researcher)

Abstract

A highly efficient and green protocol for the synthesis of pyrimido[4,5-b]quinolines has been described. The one-pot multicomponent reaction of dimedone with arylaldehydes and 6-amino-1,3-dimethyluracil in the presence of N,N-diethyl-N-sulfoethanaminium chloride ([Et3N–SO3H][Cl]) as an ionic liquid (IL) catalyst under solvent-free conditions afforded the mentioned compounds in high yields and short reaction times. Our protocol is superior to many of the reported protocols in terms of two or more of these factors: the reaction times, yields, conditions (solvent-free versus usage of organic solvents), temperature and catalyst amount.