Zinc oxide-tetrabutylammonium bromide tandem as a highly efficient, green, and reusable catalyst for the Michael addition of pyrimidine and purine nucleobases to α,β-unsaturated esters under solvent-free conditions, By Abdolkarim Zare

Research

Title	Zinc oxide-tetrabutylammonium bromide tandem as a highly efficient, green, and reusable catalyst for the Michael addition of pyrimidine and purine nucleobases to α,β-unsaturated esters under solvent-free conditions
Type	Article
Keywords	Zinc oxide; tetrabutylammonium bromide; Michael addition; pyrimidine; purine; nucleobases
Journal	Canadian Journal of Chemistry
DOI	10.1139/v08-022
Researchers	Abdolkarim Zare (First researcher) , Alireza Hasaninejad (Second researcher) , Mohammad Hassan Beyzavi (Third researcher) , Abolfath Parhami (Fourth researcher) , Ahmad Reza Moosavi-Zare (Fifth researcher) , Ali Khalafi-Nezhad (Not in first six researchers) , Hashem Sharghi (Not in first six researchers)

Abstract

An efficient procedure for the synthesis of carboacyclic nucleosides via microwave-assisted Michael addition of pyrimidine and purine nucleobases to α,β-unsaturated esters in the presence of catalytic amounts of zinc oxide (ZnO) and tetrabutylammonium bromide (TBAB) is described. The reactions proceed rapidly in good to excellent yields.Key words: ZnO–TBAB, green chemistry, Michael addition, nucleobase, solvent-free, microwave.