Ionic liquid-accelerated Michael addition of pyrimidine and purine nucleobases to α,β-unsaturated esters: a rapid approach to carboacyclic nucleosides synthesis, By Abdolkarim Zare

Research

Title	Ionic liquid-accelerated Michael addition of pyrimidine and purine nucleobases to α,β-unsaturated esters: a rapid approach to carboacyclic nucleosides synthesis
Type	Article
Keywords	Ionic liquid, Michael addition, nucleobase, Cs2CO3, carboacyclic nucleoside, microwave
Journal	ARKIVOC
DOI	10.3998/ark.5550190.0009.g06
Researchers	Abdolkarim Zare (First researcher) , Alireza Hasaninejad (Second researcher) , Roholla Safinejad (Third researcher) , Ahmad Reza Moosavi-Zare (Fourth researcher) , Ali Khalafi-Nezhad (Fifth researcher) , Mohammad Hassan Beyzavi (Not in first six researchers) , Mojtaba Miralai-Moredi (Not in first six researchers) , Esmail Dehghani (Not in first six researchers) , Parvin Kazerooni-Mojarrad (Not in first six researchers)

Abstract

Ionic liquid 1-butyl-3-methylimidazolium bromide ([bmim]Br) efficiently accelerates Michael addition of pyrimidine and purine nucleobases to α,β-unsaturated esters in the presence of catalytic amount of Cs2CO3 under microwave irradiation to give carboacyclic nucleosides in good to high yields and short reaction times.