An efficient solventless method for the synthesis of N,N-dialkyl sulfonamide derivatives, By Abdolkarim Zare

Research

Title	An efficient solventless method for the synthesis of N,N-dialkyl sulfonamide derivatives
Type	Article
Keywords	N,N-Dialkyl sulfonamide, Solvent-free, Michael addition, α,β-Unsaturated ester, NaOH, Microwave
Journal	Journal of the Iranian Chemical Society
DOI	10.1007/BF03246142
Researchers	Abdolkarim Zare (First researcher) , A. Hasaninejad (Second researcher) , A.R. Moosavi Zare (Third researcher) , A. Khalafi-Nezhad (Fourth researcher) , A. Parhami (Fifth researcher)

Abstract

Aza-Michael addition of sulfonamides to α,β-unsaturated esters efficiently proceeds in the presence of catalytic amount of sodium hydroxide (NaOH) and tetrabutylammonium bromide (TBAB) as a phase-transfer catalyst (PTC) under microwave irradiation to afford N,N-dialkyl sulfonamides as biologically interesting compounds in good to excellent yields and short reaction times.