KF/Al2O3 as an Efficient, Green, and Reusable Catalytic System for the Solvent-Free Synthesis of N-Alkyl Derivatives of Sulfonamides via Michael Reactions, By Abdolkarim Zare

Research

Title	KF/Al2O3 as an Efficient, Green, and Reusable Catalytic System for the Solvent-Free Synthesis of N-Alkyl Derivatives of Sulfonamides via Michael Reactions
Type	Article
Keywords	N-alkylsulfonamide; KF/Al2O3; Michael addition; microwave; solvent-free; sulfonamide
Journal	PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
DOI	10.1080/10426500802274625
Researchers	Abdolkarim Zare (First researcher) , Alireza Hasaninejad (Second researcher) , Mohammad Hassan Beyzavi (Third researcher) , Ahmad Reza Moosavi-Zare (Fourth researcher) , Ali Khalafi-Nezhad (Fifth researcher) , Mehrnoosh Roshankar (Not in first six researchers) , Fatemeh Fiouzi (Not in first six researchers) , Sedigheh Azad (Not in first six researchers)

Abstract

KF/Al 2 O 3 efficiently catalyzes the microwave-assisted Michael addition of sulfonamides to α,β-unsaturated esters under solvent-free conditions to afford N-alkyl derivatives of sulfonamides as biologically interesting compounds in high yields and in short reaction times. In this reaction, N,N-dialkylsulfonamides are also produced, but in very low yields.