One-Pot, Four-Component Synthesis of Novel Spiro[indeno[2,1-b]quinoxaline-11,4′-pyran]-2′-amines, By Abdolkarim Zare

Research

Title	One-Pot, Four-Component Synthesis of Novel Spiro[indeno[2,1-b]quinoxaline-11,4′-pyran]-2′-amines
Type	Article
Keywords	Multi-component reaction; spiro[indeno[2,1-b]quinoxaline-11,4′-pyran]-2′-amines; ninhydrin; 1,2-diaminobenzenes; alkyl malonates
Journal	JOURNAL OF HETEROCYCLIC CHEMISTRY
DOI	10.1002/jhet.1604
Researchers	Alireza Hasaninejad (First researcher) , Nooshin Golzar (Second researcher) , Abdolkarim Zare (Third researcher)

Abstract

A one-pot, four-component reaction for the efficient synthesis of novel spiro[indeno[2,1-b]quinoxaline-11,4′-pyran]-2′-amines by using InCl3 is described. The syntheses are achieved by reacting ninhydrin with 1,2-diaminobenzenes to give indenoquinoxalines, which are trapped in situ by alkyl malonates and various α-methylencarbonyl compounds through cyclization, providing multifunctionalized spiro-substituted indeno[2,1-b]quinoxaline-11,4′-pyran-2′-amines.