A Highly Efficient Protocol for the Synthesis of 2-Amidoalkylphenols using SO3H-Functionalized Phthalimide (SFP) under Solvent-free Conditions, By Abdolkarim Zare

Research

Title	A Highly Efficient Protocol for the Synthesis of 2-Amidoalkylphenols using SO3H-Functionalized Phthalimide (SFP) under Solvent-free Conditions
Type	Article
Keywords	2-Amidoalkylphenol, Phenol, Arylaldehyde, Amide, SO3H-functionalized phthalimide (SFP), Solid acid
Journal	Journal of Applied Chemical Research
DOI	https://sanad.iau.ir/Journal/jacr/Article/865459
Researchers	Abdolkarim Zare (First researcher) , Maryam Maghsoudi (Second researcher) , Bentolhoda Gholami (Third researcher) , Ahmad Reza Moosavi-Zare (Fourth researcher)

Abstract

A highly efficient and simple protocol for the synthesis of 2-amidoalkylphenols has been described. The one-pot multi-component condensation of phenols with aromatic aldehydes and amides in the presence of catalytic amount of SO3H-functionalized phthalimide (SFP) under solvent-free conditions afford the title compounds in high yields and relatively short reaction times. It is noteworthy that the reaction between phenols, arylaldehydes and amides has been scarcely studied in the literature (in spite of the condensation of 2-naphthol with arylaldehydes and amides, which has been extensively reported).