January 24, 2025
Abdolkarim Zare

Abdolkarim Zare

Academic Rank: Professor
Address: Department of Chemistry, Faculty of Nano and Bio Science and Technology
Degree: Ph.D in Organic chemistry
Phone: 07731222717
Faculty: Faculty of Nano and Biotechnology

Research

Title Efficient Synthesis of β-Acetamido Ketones and Esters Using Aluminum Chloride as an Inexpensive and Green Catalyst
Type Article
Keywords
β-acetamido ketone, β-acetamido ester, aluminum chloride, enolizable ketone, synthetic methods, multicomponent reactions
Journal CHINESE JOURNAL OF CHEMISTRY
DOI 10.1002/cjoc.201180460
Researchers Mohammad Ali Zolfigol (First researcher) , Ardeshir Khazaei (Second researcher) , Mohammad Mokhlesi (Third researcher) , Abdolkarim Zare (Fourth researcher) , Maliheh Safaiee (Fifth researcher) , Fatemeh Derakhshan-Panah (Not in first six researchers) , Hassan Keypour (Not in first six researchers) , Ahmad Ali Dehghani-Firouzabadi (Not in first six researchers) , Maria Merajoddin (Not in first six researchers)

Abstract

Aluminum chloride (AlCl3) efficiently catalyzes one-pot multicomponent condensation of enolizable ketones or alkyl acetoacetates with aldehydes, acetonitrile and acetyl chloride to afford β-acetamido ketone or ester derivatives in high to excellent yields and in relatively short reaction times. Moreover, by this synthetic method, some novel β-acetamido ketones and esters (i.e. one complex structure) are prepared.