Practical synthesis of some novel unsymmetrical 1,3-dialkyl pyrimidine derivatives at room temperature, By Abdolkarim Zare

Research

Title	Practical synthesis of some novel unsymmetrical 1,3-dialkyl pyrimidine derivatives at room temperature
Type	Article
Keywords	1,3-Dialkylpyrimidine, nucleobase, N3-alkylation, alkyl halide
Journal	ARKIVOC
DOI	10.3998/ark.5550190.0007.c19
Researchers	Ali Khalafi-Nezhad (First researcher) , Abdolkarim Zare (Second researcher) , Abolfath Parhami (Third researcher) , Mohammad Navid Soltani Rad (Fourth researcher)

Abstract

The efficient synthesis of some novel unsymmetrical 1,3-dialkylpyrimidines is described. N3-Alkylation of N1-substituted pyrimidine derivatives with various functionalized alkyl halides in the presence of catalytic amount of tetrabutylammonium bromide (TBAB) and Cs2CO3 in MeCN affords the title compounds. The reactions proceed at room temperature and the products are obtained in good to excellent yields.