Elements are the shared result of the erosion of rocks in the catchment area and human activities. Nutritional habits, ecological
needs, heavy metal concentrations in water and sediment, duration of fishing in the aquatic environment, fishing season, and
physicochemical properties of water (salinity, pH, hardness, and temperature) are among the effective factors in the accumulation
of heavy metals in various fish organs. In this study, 150 specimens of Rutilus kutum were collected from the southern shores of
the Caspian Sea including Astara, Anzali, and Kiashahr in Guilan Province, Farahabad in Mazandaran Province, and Bandar
Torkaman in Golestan Province from December 2018 through October 2019. It is possible to predict the metal concentrations
using the variables such as fish tissue, sampling region, and season. Akaike information criterion (AIC) was used to select the best
regression model. We used fish muscle tissue and Anzali sampling site which were considered reference variables in the
regression model. For some elements, a better model is obtained by considering all variables (AIC criterion is its lowest value).
The best model obtained for Cu, Mn, and Si was only with region (as a variable). The best model obtained for Sn and Sr only
concerns the region and tissue variables. The best model obtained for Sb only related to tissue variable. Using these models,
environmental monitoring becomes easier and cheaper. We suggest further studies to be carried out in the shortest possible time
along with the least laboratory cost.