Decreasing low molecular weight can improve the digestibility and availability of ingredients
such as sodium alginate. This study aimed to test the four dosages of low molecular weight sodium
alginate (LMWSA) (0%: Control, 0.05%: 0.5 LMWSA, 0.10%: 1.0 LMWSA, and 0.2%: 2.0 LMWSA) in
whiteleg shrimp (Litopenaeus vannamei) (3.88 0.25 g) for eight weeks. After finishing the trial, shrimp
were exposed to cadmium (1 mg/L) for 48 h. While feed conversion ratio (FCR) improved in shrimp
fed dietary 2.0 LMWSA (p < 0.05), there was no significant difference in growth among treatments.
The results showed a linear relation between LMWSA level and FCR, and glutathione S-transferase
(GST) before; and malondialdehyde (MDA), glutathione (GSH), GST, and alanine transaminase (ALT)
after cadmium stress (p < 0.05). The GST,MDA, ALT, and aspartate transaminase (AST) contents were
changed after stress but not the 2.0 LMWSA group. The survival rate after stress in 1.0 LMWSA (85.23%)
and 2.0 LMWSA (80.20%) treatments was significantly higher than the Control (62.05%). The survival
rate after stress negatively correlated with GST and ALT, introducing them as potential biomarkers for
cadmiumexposure inwhiteleg shrimp. Accordingly, the 2.0 LMWSAtreatment had the best performance
in the abovementioned parameters. As the linear relation was observed, supplementing more levels of
LMWSA to reach a plateau is recommended.