Dariush Saberi

A one-pot multi-component pathway is reported to synthesize novel spiro-(1,8)-naphthyridine derivatives in good to excellent yields via the condensation reaction of isatin derivatives, malononitrile dimer and enamine derivatives. In polyethylene glycol-400 at 80°C, more than 30 novel products of spiro-(1,8)- naphthyridines were synthesized up to 95% yields with only water as a by-product. Separation of the products was performed efficiently and no additional operation was needed for purification of the products, except that, in some cases, recrystallization was done. Moreover, some new spiro-dihydropyrimidines were efficiently synthesized when malononitrile (or methyl/ethyl-2-cyanomalonate) was employed instead of enamines.