ChCl:Urea deep eutectic solvent as a green media for one-pot, three-component catalyst-free synthesis of spiro-benzoxazole derivatives, By Dariush Saberi

Research

Title	ChCl:Urea deep eutectic solvent as a green media for one-pot, three-component catalyst-free synthesis of spiro-benzoxazole derivatives
Type	Article
Keywords	Deep eutectic solvent; Choline chloride; Catalyst-free; Isatin; Dihydrobenzoxazole; Spiro-benzoxazoles
Journal	JOURNAL OF MOLECULAR LIQUIDS
DOI	10.1016/j.molliq.2024.125537
Researchers	fatemeh asilpour (First researcher) , Dariush Saberi (Second researcher) , Alireza Hasaninejad (Third researcher)

Abstract

An efficient catalyst-free procedure is reported for the one-pot three-component synthesis of novel spiro-benzoxazole derivatives via the condensation reaction of isatins, dihydrobenzoxazole compounds, and malono derivatives in ChCl:Urea deep eutectic solvent, as a green reaction medium. Spiro-benzoxazoles were easily extracted from the reaction mixture, by adding water, and isolated in good to excellent yields